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Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

  • Ketoconazole, itraconazole (used to manage fungal infection)
  • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
  • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
  • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
  • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

  1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
  2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
  3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
  4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.
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ContraindicationsRiskotix/Stata/Medikin/PharmacysStata/Health/ushcheter
Nitrates/Alpha-blockersRequires prior consultation.
Alpha-blockers

C.

Nitrates and nitrite medications both lower blood pressure, leading to a significant and potentially life-threatening drop in blood pressure (hypotension). While this interaction is less severe than with medications used alone or in combination with other medications, it can still cause dizziness or fainting in sensitive individuals. In addition, high-fat foods can delay the onset of nitrates and alpha-blockers by reducing their effectiveness.

5.

Whether you can take Tadalafil at the same time as your other medications will depend on which medications you are taking.

You are required to complete a short medical consultation questionnaire that asks for any medications that you are prescribed from your GP and will indicate the medications that can’t be taken alongside Tadalafil.

There are several medicines which should not be taken concurrently with Tadalafil. Medicines which can have potentially serious interactions with Tadalafil include :-

• Any alpha-blocker medicines e.g. doxazosin (Cardura), alfuzosin (Xatral), tamsulosin, terazosin, or Flomax, that you can buy in the pharmacy. (These medicines may be used to treat prostate problems or high blood pressure).

• Isosorbide mononitrate, isosorbide dinitrate, or use a GTN spray or tablets

for chest pain or use Rectogesic ointment?

• Nicorandil (Ikorel), used to treat angina

• Cimetidine, used to treat stomach or duodenal (peptic) ulcers

• Theophylline, used to treat asthma

• Antibiotics:- Clarithromycin, Erythromycin and Telithromycin

• Anti-fungals such as itraconazole and ketoconazole

• Seizure medication:- carbamazepine, oxcarbazepine, phenobarbital, phenytoin and primidone

• Heart or blood pressure medication:- disopyramide, amiodarone, quinidine and procainamide

• Anti-viral medication:- telaprevir, atazanavir, retonavir, indinavir, saquinavir and cobicistat

• Recreational drugs:- amyl nitrate (poppers)

If you are taking any prescribed medication from your GP then you can simply write those in the “Is there any other medical information that you think our doctor should know?” section on the medical questionnaire. Then, our doctor will know whether the Tadalafil is safe for you to take.

Read available consultation questionnaire

What is Tadalafil?

Tadalafil is the generic version of the PDE5 inhibitor.

Tadalafil is used to treat 18 conditions:

• erectile dysfunction- difficulty getting or keeping an erection - Sildenafil (alprazoliazepone) and Tadalafil (generic Cialis).

• kidney or liver impairment - Tadalafil (generic Cialis) or sildenafil (generic Viagra)

• adult men with a known hypersensitivity to tadalafil or to any of the other ingredients of this medicine.

This medicine: Is Tadalafil safe?

The Tadalafil is generally considered as little as 25 days for major erectile dysfunction and as little as 4 days for common erectile dysfunction. However, there is a risk of delayed onset of an erection when taking this medicine especially when taking it on an frequent basis.

therefore it's important that you take Tadalafil on an as-needed basis as it could happen which may reduce its effectiveness.

Who can use Tadalafil?

Tadalafil is not suitable for everyone.

There are several people who can potentially use Tadalafil and it's only usually only taken once every 24 hours. In this case, it's best to take it 5 times a day with food.

-ijuana - An allergic reaction is usually avoided when taking Tadalafil since the symptoms can be severe and only be treated by specialist treatments such as sildenafil.

-uminium - There are a number of different types of -uminium available and our doctors will only consider these if they have a good tolerance and work well.

Who should not use Tadalafil?

Tadalafil can interact with other medicines and substances and can be dangerous for patients as it can helpisbury dizziness, headache, or heartburn.

Cialis has been shown to cause some mild side effects. Talk to your health care provider if these do not go away within a few days. If you begin to experience more serious reactions, seek medical attention immediately.

Common side effects reported from Cialis use include:

  • Headache
  • Indigestion
  • Heartburn
  • Upset stomach
  • Gas
  • Nausea
  • Flushing

More severe side effects include:

  • Painful erections or erections that last longer than 4 hours
  • Sudden loss of vision
  • Sudden loss of hearing
  • Ringing in the ears
  • Chest pain
  • Shortness of breath
  • Painful urination
  • Increased urination frequency
  • Fainting
  • Dizziness
  • Skin rash
  • Hives
  • Facial swelling

If you experience any of these side effects, seek medical attention immediately. These are symptoms of a severe adverse reaction to this medication that require immediate treatment.

As with all prescription medications, inform your doctor of any medical conditions you currently manage. Tell them about any and all medications, prescription drugs, and supplements you are taking before starting treatment with Cialis. Cialis can interact with bodily substances, causing potentially serious adverse reactions.

Specifically, you should inform your health care provider of any alpha-blocker, antifungal, HIV protease inhibitor, or high blood pressure medication you are taking. Remember to mention any herbal products you use, especially St. John’s wort.

In addition, let your doctor know if you have recently had heart surgery or experience chest pain during sex. If you experience any changes in your heartbeat or chest pain during sex, contact your health care provider immediately.

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Common Side EffectsOther Cialis side effects may occur in some patients taking Cialis with these side effects:nausea Most people taking Cialis with these side effects may not experience any side effects from the medication. However, if you experience any severe or persistent side effects, such as severe dizziness, fainting, heart problems, lightheadedness, headache, or prolonged erections, please seek medical attention immediately.

Cialis can cause other side effects which should not be discussed with a doctor. However, everyone should discuss their health status and medication needs, especially if they are taking other medications.Sign up for our free mail list.

Note: Cialis may cause serious side effects if you take it with any of the following:

  • Alcohol
  • Grapefruit
  • High blood pressure medication
  • Some recreational drugs
  • Liver or kidney problems
  • Low sodium levels

In addition, tell your doctor if you have or have ever had heart, kidney, or liver problems. If you have, or have ever had, a heart problem, low sodium levels, diabetes, or high blood pressure, please tell your doctor.

In the US, you will be asked a series of questions about your health before you can take Cialis. For example, if you have ever had an allergic reaction to tadalafil or any other medicine, you will be asked a series of questions about your health before you take Cialis. For the purposes of this evaluation, you will refer to the health problems that Cialis caused with these symptoms.

References

1. KD. Tripathi. Androgens and Drugs for Erectile Dysfunction. Essentials of medical pharmacology. Seventh edition. 2013. Page-304.

2. Adam M Henrie, James J Nawarskas, and Joe R Anderson. Clinical utility of tadalafil in the treatment of pulmonary arterial hypertension: an evidence-based review. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. November 2015. [Accessed on November 08th, 2023]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636095/

3. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in October 2021] [Accessed on November 08th, 2023]https://www.medicines.org.uk/emc/files/pil.8637.pdf

4. Leeford Healthcare Private Ltd. Bigfun-36.https://www.leeford.in/product/556/bigfun-36

5. Central Drugs Standard Control Organization. Tadalafil tablet 20 mg (Additional Indication). [Revised in November 2009]. Tadalafil 10mg/20mg Tablets. [Revised in September 2003] [Accessed on November 08th, 2023]https://cdscoonline.gov.in/CDSCO/Drugs

cgf. IST.gov/CDSCO-Tadalafil- Nawarkas.ijk/Treatments/Tadalafil-For Use in Pulmonary Arterial Hypertension.https://www. IST.gov.in/ifestyle/therapeutic-products/TadalafilCDSCO.gov.in/ifestyle/therapeutic-products/Tadalafil

Categories

Cialis, Tadalafil

sexes and gender[1]:

  • Breast- tenderness and enlargement [2]:
  • Headache or dizziness[3]:
  • Back pain or muscle pain[4]:

Cialis is indicated for adult males who have not yet reached the age of 18 years.

  • Breast- tenderness and enlargement[4]:

                Cialis 20 mg, Tadalafil

                Cialis 20 mg, Tadalafil is used to treat erectile dysfunction in men. It is used to treat benign prostatic hyperplasia (BPH), also called pulmonary arterial hypertension. This medication is not approved for the treatment of pulmonary arterial hypertension.

                This medicine is taken by mouth. Do not take this medicine if you are already taking nitrates (eg, isosorbide, isosorbide mononitrate) or amyl nitrate (eg, Nitro-Dur, Nitromist, Isosorbide D, Isosorbide Mononitrate, Sorbitol). If you are not sure, ask a doctor.

                Take this medicine with or without food, usually 1 to 2 hours before sexual activity. Take the medicine approximately 60 minutes before you plan to have sex.

                The daily dosage may be increased to a maximum of four or more times a day depending on the severity of the symptoms and your doctor's advice.

                Do not take more often than once daily, even if you don't feel any improvement in your condition right away.

                Tadalafil is a medicine that belongs to a group of medicines called PDE5 inhibitors. These medicines work by blocking the enzyme responsible for the breakdown of cGMP in the corpus cavernosum, which is responsible for the relaxation of smooth muscle in the penis. This improves blood flow and the ability to achieve and maintain an erection.

                Tadalafil 40 mg, Cialis 20 mg, Tadalafil

                Tadalafil is used to treat erectile dysfunction (ED). It is available in tablet form and is taken by mouth. Take Tadalafil as your doctor prescribes the medication.

                Cialis 20 mg, Tadalafil is a medicine that belongs to a group of medicines called PDE5 inhibitors.

                Tadalafil 20 mg, Cialis 20 mg, Tadalafil